Imperial College London
Dr James Flanagan, completed his PhD in 2002 at the Queensland Institute of Medical Research in Brisbane, Australia, and has pursued postdoctoral work in Cancer Genetics, Epigenetics and Cancer Epigenetics. He was awarded a Breast Cancer Campaign Scientific Fellowship (Imperial, 2009-2014) and is now a Senior Lecturer (2014-present) in the Division of Cancer, Dept. of Surgery and Cancer, Faculty of Medicine at Imperial College London. He was awarded the British Association of Cancer Research Translational Researcher Award in 2011 and is the principal investigator for the OCA funded programme "Risk and Prevention" based in the Ovarian Cancer Action Research Centre. Current research is aimed at investigating epigenetic alterations as a mechanism for carcinogenesis and investigating the hypothesis that epigenetic variation may be a driver of cancer risk whether by inherent constitutional variation or as a mediator of other cancer risk factors.
Epigenetic biomarkers for platinum response in ovarian cancer
Platinum based chemotherapy is the standard of care for ovarian cancer patients at first line treatment and often at subsequent relapses. We have identified and validated an epigenetic biomarker detectable in blood DNA that predicts whether a patient should be treated with platinum after relapse. We propose a mechanism by which platinum-adduct DNA repair causes the epigenetic changes and that the genomic and epigenomic location of platinum adducts defines sensitivity.
EVEN MORE SEMINARS
Professor Anthony Howell The University of Manchester / The Christie NHS Foundation Trust
Improving risk estimation of breast cancer
Dr Tony Dhillon University of Surrey and Royal Surrey County Hospital
Immunotherapy and Colon Cancer
Dr Khurum Khan University College London Hospitals
Translational research in GI Oncology- how to make progress?
Dr Abeer Shabaan Queen Elizabeth Hospital Birmingham & University of Birmingham
Breast Pathology: Assessing tumour response to neoadjuvant chemotherapy and endocrine therapy– Pathological considerations
Dr Shanmugasundaram Ramkumar University Hospital Southampton NHS Foundation Trust
Radiotherapy developments in management of recurrent rectal cancers