Novel Antibody Therapy for the Treatment of Blood Cancers

CREATION of a new antibody by researchers may provide an effective alternative treatment for multiple blood cancers, including non-Hodgkin lymphoma, multiple myeloma, and acute myeloid leukaemia (AML). Until now, treatments for these malignancies have failed to remove cancerous cells from the bone marrow; an essential step in successful treatment.

By recognising the level of protection that the bone marrow provides for cancer cells, Dr Flavia Pernasetti, Pfizer Oncology Research and Development, San Diego, California, USA, and colleagues, focussed their study on finding ways to drive the cancer away from the bone marrow; therefore, limiting the nourishment of the cancer cells. The team developed a novel antibody (PF-06747143), which interacted with the CXCR4 chemokine receptor involved in controlling the movement of cells into the bone marrow. Preclinical research showed that the antibody acted in two ways: 1) by moving the cells into the peripheral blood stream, where they could be destroyed by other treatments; and 2) by attacking and killing the cells directly...

Written by European Medical Journal (EMJ)